ADHD

ADHD : why you can’t “switch off”

My brain feels like a race car without brakes. Competing thoughts racing around simultaneously,  one leading to another seemingly unrelated, but yet related thought. For example: “I need to hang up the washing” (goes to hang up washing)> “oh yes, I need washing powder”> “I also need to buy cat food”> “I wonder where she is?” (abandons hanging up the rest of the washing to look for cat). Then spends 10 minutes cuddling the cat. Goes back to desk and continues working but thirty minutes later suddenly remembers the wet washing still in the basket outside and rushes off to hang it up.  This is just one small example of my life with ADHD. It is annoying, frustrating and often feels like you just can’t anything productive done.   The Default Mode Network But did you know that there is a logical reason for this? We have a set of brain regions called the Default Mode network (DMN) which include the ventrolateral and ventromedial prefrontal cortex, the posterior cingulate cortex (PCC), the cuneus, and the inferior parietal lobe. These areas are activated spontaneously when we’re awake or when we are not focused on a specific task, or when at rest, like when daydreaming, thinking about feelings, ruminating, or imagining. It’s also active when we are processing information about ourselves. The problem with most of us with ADHD, is that this area of our brain seems to stay activated ALL THE TIME. This is where obsessively worrying about something, ruminating over past mistakes or conversations, or catastrophising (imagining worst case scenarios) comes in. So when we need to activate our TPN (task positive network) for focusing on the task at hand, our DMN doesn’t disengage, making it challenging to stay focused on what we’re supposed to be doing. In Neurotypical people, the DMN can disengage when the TPN switches on and visa versa. But because ADHD is a neurodevelopmental disorder of the brain, this process is harder for us.  While it can have it’s advantageous: being creative, thinking out-the-box, coming up with unconventional ideas on how to solve problems or complete tasks, it can also be frustrating and counter productive.    How to manually switch over In neurotypical brains, these networks function like a seesaw, with one activating while the other is suppressed. In ADHD, this “seesaw” mechanism is faulty, leading to simultaneous activation and competition that disrupts focus. The DMN and TPN compete for control, causing the mind to be easily pulled away from tasks by internal thoughts and daydreams. This manifests as distractability and difficulty with sustaining attention.   One study found that the stimulant medication methylphenidate (Ritalin) can help normalize the brain circuits in individuals with DMN dysfunction. It suppresses the DMN, so that the TPN can engage as needed,  and this improves task performance.   While the switch from the Default Mode Network (DMN) to the Task-Positive Network (TPN) isn’t like flipping a light switch, you can manually trigger this shift by engaging in concrete, external-focused actions and mindfulness practices. By consciously interrupting DMN-driven thought processes like daydreaming or rumination, you can activate the TPN for better concentration. Here are some practical steps you can try to do this manual switch. Get in touch with your senses  Try breathing in and breathing out for a count of 4 to shift your brain’s focus from internal thoughts to a deliberate, physical task. Name 5 things you can see, 4 things you can hear, 3 things you can feel, 2 things you can smell, and 1 thing you are grateful for. Stand up and stretch, walk around, make a cup of tea. Physical movement is like a reset button for the brain that helps you re-engage with your work. For those with ADHD, a fidget tool can serve as a non-distracting way to satisfy the brain’s need for stimulation.  Engage with your environment Minimize external distractions by tidying your work area or using noise-canceling headphones. A focused environment helps prime the brain for task-positive work. If possible, move to a new location, such as a quiet café, a park bench, or even just a different room. Novel surroundings can help break the cycle of a wandering mind. For some, complete silence is a distraction. A low-level noise source, such as instrumental music, brown noise, or coffee shop sounds, can provide a consistent sensory input that keeps the DMN from taking over. Implement structured tasks Overwhelming tasks can trigger “ADHD paralysis.” By breaking a large task into small, manageable steps, you create a series of smaller tasks that are easier to start and complete. Use the Pomodoro Technique. This time management method breaks work into timed intervals (e.g., 25 minutes of work, 5 minutes of rest). The structured breaks allow the DMN to relax, which can prevent it from taking over during a work period. Try to make a tedious chore or assignment more interesting. Time yourself to see how quickly you can do it, or offer yourself a small reward for completion. This adds a layer of challenge that holds your brain’s attention. Reframe and redirect your thoughts When you notice your mind wandering, mentally “note” or “label” the thought without judgment (e.g., “rumination,” “worry,” or “planning”). Then, consciously redirect your attention back to the task at hand. If your DMN often pulls you into anxious rumination, schedule a specific time of day to intentionally think about your worries. This helps train your brain to postpone stressful thoughts rather than having them hijack your focus during important tasks. Taking one concrete, goal-directed step—even if it’s tiny—activates the TPN. If you are ruminating on a project, just writing one sentence or defining one small task can be enough to get the momentum going. Try these practical steps and see if they make a difference! I use a lot of these in coaching and on myself and I can say they definitely work, but it is good to see which ones fit with you.   References: Querne L, Fall S,

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ADHD and Addictions

How you can feel when you have ADHD   Our brains have a pathway called the Dopaminergic pathway, which controls how we feel pleasure, think, remember things, and move our bodies. When things go out of balance in this pathway, it can make us more likely to struggle with addictive behaviors like using substances excessively or engaging in risky activities. Did you know that up to 50% of individuals with continuing ADHD symptoms have a substance-use disorder?   If you have ADHD, you might have symptoms like feeling restless, having trouble controlling your mood, or feeling overwhelmed.  You are seeking the very thing that your brain struggle with: dopamine. You are on a constant quest for something that will help you feel normal, like you belong. That will quieten the constant noise in your head and give you peace. But for most of us with ADHD, peace often eludes us… Because of these feelings, you might try to find ways to calm down and get rid of the anxiety.   Why many with ADHD have addiction problems   ADHD can affect your ability to make decisions, use judgement and practice self- control, you might end up turning to substances that temporarily make you feel less restless or anxious, and more like everyone else. This feeling of relief can be addictive, leading to a cycle of substance abuse.   Research shows that people with ADHD often have genes that make them more likely to develop addictive behaviors. ADHD is a condition that affects the structure and function of the brain, as well as how certain chemicals in the brain, like dopamine, and other neurochemicals work.   Many people with ADHD don’t realize they’re seeking substances to help them feel “normal.” Even after being diagnosed, some still struggle with substance abuse. However, treatments like medication or supplements can help manage ADHD symptoms and reduce the risk of substance abuse. (substance abuse refers to alcohol, nicotine and possibly even other drugs)   It’s important to understand how ADHD affects your brain and why you might be more prone to addictive behaviors. Substance abuse can make ADHD symptoms worse and cause other health problems. If you’re struggling, it’s essential to seek help from medical and mental health professionals who can offer safer and healthier ways to cope.   How genetic testing can help The DNA Resilience test looks at 7 neurochemicals to see how well you can handle stress and difficulties. And the DNA Mind test looks at Neurodegenerative disorders, Mood regulation and Addictive behavior – Risk for alcohol, nicotine, cannabis and opioid dependence, psychosis response from cannabis use, eating disorders (binge eating), ‘adrenaline seeking’ or risk-taking behavior. These two tests together can help someone with ADHD to get personalized advice on diet, supplements, exercise, and lifestyle changes to optimize your resilience and improve your overall health. I also recommend my clients get a functional test to look at neurochemical metabolite levels, micronutrients, amino acids, fatty acids and proteins. Contact me for more info on these tests to orders yours and receive nutrigenetic feedback.   Interested in learning more about genetics and epigenetics? Then sign up for my exclusive membership here . This membership gives you access to a wealth of information for life! With a single once-off fee. Increase your knowledge and learn how to improve your genetic expression.   Sources: Sullivan MA, Rudnik-Levin F. Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Ann N Y Acad Sci. 2001 Jun;931:251-70. doi: 10.1111/j.1749-6632.2001.tb05783.x. PMID: 11462745. Zulauf CA, Sprich SE, Safren SA, Wilens TE. The complicated relationship between attention deficit/hyperactivity disorder and substance use disorders. Curr Psychiatry Rep. 2014 Mar;16(3):436. doi: 10.1007/s11920-013-0436-6. PMID: 24526271; PMCID: PMC4414493. Anker E, Haavik J, Heir T. Alcohol and drug use disorders in adult attention-deficit/hyperactivity disorder: Prevalence and associations with attention-deficit/hyperactivity disorder symptom severity and emotional dysregulation. World J Psychiatry. 2020 Sep 19;10(9):202-211. doi: 10.5498/wjp.v10.i9.202. PMID: 33014721; PMCID: PMC7515748.  

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Slow COMT, Estrogen and ADHD

(see my post for Fast COMT)   What are catecholamines?   Catecholamines, which include dopamine, norepinephrine and epinephrine, are neurotransmitters made from the amino acid tyrosine. These chemicals are present in the central and peripheral nervous systems and are linked to pain and mood disorders. An imbalance of catecholamines have been found in people with chronic pain conditions like fibromyalgia and mood disorders like depression and anxiety. The COMT enzyme helps break down catecholamines. When COMT activity is low, it leads to higher dopamine levels in the brain. Dopamine is crucial for regulating emotions, pain perception, motivation, and behavior. Both COMT and dopamine receptors work together to maintain a balance in dopamine transmission, and an imbalance can lead to increased pain sensitivity and depression.   What is COMT? We all have a COMT gene.  COMT stands for catechol-O-methyltransferase. There are three variants of this gene, simply known as fast, slow or Intermediate. The COMT enzyme encodes the COMT gene which is involved in the breakdown of estrogen, caffeine and various catecholamine’s like dopamine, norepinephrine and epinephrine. COMT is part of an important biological pathway in the body called Methylation and is part of your dopaminerigic pathway. Slow COMT is known as met/met, AA or written as +/+. If you have a slow COMT, this means that the COMT enzyme that encode the COMT gene is slowed in it’s activity to break down estrogen and catecholamines like dopamine, norepinephrine and epinephrine. This could mean you can have higher levels of these. This isn’t necessarily a good thing.   What are some symptoms/signs of slow COMT? Here are some common symptoms or signs that you could have a slow COMT variant: You are prone to anxiety and mood disorders You have a good memory You can concentrate and pay attention quite well but get bored You don’t do well with caffeine or other stimulants, they tend to make you feel anxious You get stressed quite easily and have trouble calming down You have OCD tendencies You tend to be a workaholic It takes you a long time to calm down after you are upset You struggle with sleep You are easily irritated or annoyed You tend to react badly to anti-depressants You are energetic and some may describe you as hyperactive You are perhaps an extrovert and like to socialize You have menstrual issues and have experienced fibroids and PMDD   Slow COMT and Estrogen With estrogen, higher levels bring about their own problems such as: *weight gain *unpredictable periods with light or heavy bleeding *irritability *uterine fibroids *certain cancer such as breast, ovarian *anxiety   Slow COMT and ADHD With ADHD and high levels of dopamine, norepinephrine and epinephrine we start to see things like hyperactivity, impulsivity, mood disorders, inability to calm down or relax, more stress, insomnia and maybe more aggression.   Stimulants and Anti-depressants For people with slow COMT, they don’t react well to stimulants like caffeine and green tea and also do not always tolerate stimulant ADHD meds well or antidepressants. This is because they already have higher baseline levels of certain neurochemicals, and sometimes, this can cause an imbalance between them making a bad situation worse. For those with ADHD and slow COMT, they do not tend to react well with stimulants such as Ritalin, Adderall, and Vyvanse but do better on a non stimulant such as Intuniv.   So what do you do?   Getting support for your slow COMT This is what I do as a nutrigenetic practitioner and nutritional health coach. By getting your DNA tested through me, I help you understand what it is happening and provide you with the education, and recommendations to improve your ADHD, hormones, and cognitive function.   Carrying a slow COMT gene does  not mean it is behaving that way, it depends on how it is being influenced through epigenetics, such as what you are eating, your lifestyle, stress management and so on and these are the things we delve into so that you can improve your health and support it on a genetic level.   Contact me for more information if you recognize yourself in this and want more support.     Thrive By Design Membership Thrive by Design helps you learn to support your genes through epigenetics . Your genes are the blueprint, but you are the architect.

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