Genetic Testing

Perimenopause: 3 less common signs it’s begun

Perimenopause: a word that often strikes fear into the heart of any woman, especially for those not yet on this journey. I’m sure you are aware of the most common symptoms that you’ve begun this hormonal roller coaster: hot flushes, night sweats and sleep issues are the most common ones we hear about. But did you know there are less obvious symptoms? In hindsight, I know I  started perimenopause at the age of 41. So for me, I’ve been on this road for a few years already.  I’m sharing this information based on my own experience but also what on the research says. Each woman experiences perimenopause differently, but that’s why it’s good to hear about these differences, so that, when it happens to you, you’ll know what to look out for.   Dry skin I’ve always had dry skin, but this took on a whole new meaning. Lathering body cream on daily became necessary. I also started drinking more water to try curb the dry skin. Why do we get dry skin? Estrogen normally helps the skin maintain moisture by stimulating collagen and elastin production (which keep skin plump and firm). As estrogen declines in perimenopause, all of these processes slow down, leaving skin thinner, less elastic, and drier. Fun fact: those with fast COMT tend to experience this even more as their estrogen levels are much lower. Itchy skin With dry skin often comes itchy skin. I have spent years with recurring itch especially on my stomach. No rash, no dermatitis, no eczema. There is nothing there, it’s just itches for days then goes away. Only to return again. Why does the skin itch? Again, it comes down to less estrogen. Estrogen boosts sebum (oil) which keeps the skin plump. With less estrogen, the skin barrier loses moisture, and dries out. Dry skin is more prone to itchiness and irritation. Reduced collagen and elastin make skin thinner and less resilient. Estrogen also has a role in modulating nerve signals. When levels drop, nerves may fire more erratically, causing sensations like itching, crawling, or tingling (sometimes called formication). What helps? Keeping your skin moisturized avoiding hot showers (opt for like warm water or better yet, end your shower with a blast of cold water!). Staying hydrated wearing breathable clothes like cotton and linen. switching to more natural ingredients in your body care products. using a natural bath oil helps a lot to lock moisture in before bed. The itching drove me crazy for years, until it went away completely after introducing chasteberry and wild yam. (or natural progesterone cream)     FB (Fibrocystic Breasts) FB is a painful condition. It is often confused with breast pain associated with PMS symptoms. While this condition is associated with monthly hormonal changes, it differs from the breast pain that often occurs during the luteal phase.  It often causes lumpy tissue in the breasts that can sometimes be filled with fluid called cysts that can get quite large (think golf ball size) that sometimes need drainage by means of a fine needle aspiration. These cysts can last for days or even weeks. I was diagnosed with this in my early twenties and have had to have this done from time to time. Some clinical studies have shown a significant decrease in breast pain and tenderness in women with fibrocystic breast after treatment with chasteberry extracts [source] I can attest to this! When I take chasteberry, I no longer get these painful cysts.   What can help? Chastberry (vitex agnus-castus) Chasteberry is a fruit of a shurb long used in herbal medicine, especially for women’s reproductive and hormonal health.It can be in capsule, tincture or tea form. Chasteberry influences the pituitary gland and helps balance estrogen and progesterone. It can raise progesterone indirectly by supporting luteinizing hormone (LH). By smoothing out hormone swings, it may reduce skin reactivity, dryness, and itch. [source] Interestingly, it is also fantastic for women with PMDD (PMS that is often more severe in women with ADHD) as it influences dopamine activity. [source]. The release of prolactin (a hormone) from the pituitary gland is normally controlled by dopamine, a chemical messenger in the brain that keeps prolactin levels down. Just before a period (in the late luteal phase), dopamine’s control is a bit weaker, which can cause prolactin levels to rise slightly. Higher prolactin levels have been linked to breast pain and some PMS symptoms. Studies have shown that dopamine agonists like, bromocriptine has been shown to lower prolactin levels and reduce breast pain , as well as FB.   Progesterone support Perimenopause isn’t just about low estrogen — it’s about fluctuating hormones. Sometimes estrogen is high, sometimes low, often in relation to lower progesterone. Adding progesterone (or progesterone-supporting herbs like Vitex) can restore a more stable balance, which may calm symptoms that don’t respond well to estrogen alone.   A word of Caution While I am all for natural products as far as possible, this does not mean that everybody will benefit or react in the same way. The way we each respond to different supplements or substances is tied into our metabolic health, biological health, hormonal health, genetics and much more. I have had clients inform me of their individual response to things like chasteberry and progesterone. Therefore, one should always approach these things with caution and having done your own research. I also suggest that one never stacks supplements or products. It is always better to use one product at a time for a few weeks and to keep a written record of when you start, as well as any symptoms and changes you experience, good or bad. This can help determine if a new reaction (whether good or bad ) correlates to the product. Of course these 3 symptoms or signs can be attributed to many things and needs to taken into context. You can consult your medical practitioner or see an Endocrinologist or gynecologist.   Looking for hormonal support? knowing your hormonal genetics can

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ADHD and Addictions

How you can feel when you have ADHD   Our brains have a pathway called the Dopaminergic pathway, which controls how we feel pleasure, think, remember things, and move our bodies. When things go out of balance in this pathway, it can make us more likely to struggle with addictive behaviors like using substances excessively or engaging in risky activities. Did you know that up to 50% of individuals with continuing ADHD symptoms have a substance-use disorder?   If you have ADHD, you might have symptoms like feeling restless, having trouble controlling your mood, or feeling overwhelmed.  You are seeking the very thing that your brain struggle with: dopamine. You are on a constant quest for something that will help you feel normal, like you belong. That will quieten the constant noise in your head and give you peace. But for most of us with ADHD, peace often eludes us… Because of these feelings, you might try to find ways to calm down and get rid of the anxiety.   Why many with ADHD have addiction problems   ADHD can affect your ability to make decisions, use judgement and practice self- control, you might end up turning to substances that temporarily make you feel less restless or anxious, and more like everyone else. This feeling of relief can be addictive, leading to a cycle of substance abuse.   Research shows that people with ADHD often have genes that make them more likely to develop addictive behaviors. ADHD is a condition that affects the structure and function of the brain, as well as how certain chemicals in the brain, like dopamine, and other neurochemicals work.   Many people with ADHD don’t realize they’re seeking substances to help them feel “normal.” Even after being diagnosed, some still struggle with substance abuse. However, treatments like medication or supplements can help manage ADHD symptoms and reduce the risk of substance abuse. (substance abuse refers to alcohol, nicotine and possibly even other drugs)   It’s important to understand how ADHD affects your brain and why you might be more prone to addictive behaviors. Substance abuse can make ADHD symptoms worse and cause other health problems. If you’re struggling, it’s essential to seek help from medical and mental health professionals who can offer safer and healthier ways to cope.   How genetic testing can help The DNA Resilience test looks at 7 neurochemicals to see how well you can handle stress and difficulties. And the DNA Mind test looks at Neurodegenerative disorders, Mood regulation and Addictive behavior – Risk for alcohol, nicotine, cannabis and opioid dependence, psychosis response from cannabis use, eating disorders (binge eating), ‘adrenaline seeking’ or risk-taking behavior. These two tests together can help someone with ADHD to get personalized advice on diet, supplements, exercise, and lifestyle changes to optimize your resilience and improve your overall health. I also recommend my clients get a functional test to look at neurochemical metabolite levels, micronutrients, amino acids, fatty acids and proteins. Contact me for more info on these tests to orders yours and receive nutrigenetic feedback.   Interested in learning more about genetics and epigenetics? Then sign up for my exclusive membership here . This membership gives you access to a wealth of information for life! With a single once-off fee. Increase your knowledge and learn how to improve your genetic expression.   Sources: Sullivan MA, Rudnik-Levin F. Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Ann N Y Acad Sci. 2001 Jun;931:251-70. doi: 10.1111/j.1749-6632.2001.tb05783.x. PMID: 11462745. Zulauf CA, Sprich SE, Safren SA, Wilens TE. The complicated relationship between attention deficit/hyperactivity disorder and substance use disorders. Curr Psychiatry Rep. 2014 Mar;16(3):436. doi: 10.1007/s11920-013-0436-6. PMID: 24526271; PMCID: PMC4414493. Anker E, Haavik J, Heir T. Alcohol and drug use disorders in adult attention-deficit/hyperactivity disorder: Prevalence and associations with attention-deficit/hyperactivity disorder symptom severity and emotional dysregulation. World J Psychiatry. 2020 Sep 19;10(9):202-211. doi: 10.5498/wjp.v10.i9.202. PMID: 33014721; PMCID: PMC7515748.  

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Estrogen Dominance : risk for cancer

Estrogen dominance affects many women in ways they might not realize. For example, did you know that PMS is a form of estrogen dominance? What is estrogen dominance? How does it happen? How is estrogen metabolized? How does too much estrogen lead to cancer? These are all questions this article will cover.   What is Estrogen Dominance/imbalance? Estrogen is known as the female hormone, although men have it too, just in smaller amounts with higher testosterone. It is is involved in reproduction and daily functioning, affecting mood, cognitive health, our skin, bone health and so much more. Sometimes estrogen becomes imbalanced. We might have too much estrogen compared to progesterone. Estrogen dominance happens when it starts to take the dominant role. Other factors influence this too: our genes our diet, lifestyle and environment our liver function You might not even know you have estrogen dominance, because it is not necessarily about having high levels of estrogen. It could simply be that you don’t have enough counterbalancing hormones like progesterone to mitigate the effect of estrogen in your body.   How Estrogen dominance happens Estrogen needs to be broken down and metabolized by certain enzymes in the liver and the gut before it can be safely excreted naturally. There are three pathways in which this happens. Each pathway determines whether estrogen will be converted into a good or a bad metabolite. The 2-OH is the good pathway, allowing good estrogen metabolites that support  a healthy mood, libido, and reproductive health. This is the pathway we want to encourage our body to use and has the least associated health risks. The 4-OH and 16 OH pathways are considered bad pathways because they produce estrogen metabolites that can cause cancer, low mood, PMS, PMDD and more. We are exposed to synthetic estrogens on a daily basis, called xenoestrogens. These are fake estrogens that mimic real estrogen. Your body does not know how to tell the difference.  These are found in our diet (hormones and antibiotics that animals are given; preservatives and food dyes; pestisides and fungicides on food; caffeine, alchohol) our lifestyle (certain medications, HRT, birth control pills) environment ( plastics, chemicals, pollution, skin and body products, household cleaning products, perfumes, sprays, sunscreen) These xenoestrogens are often stored in fat cells. The more fat you have, the more estrogen you are likely to have. Especially the fat on your midsection and thighs. Fat loves to absorb estrogen and elevated estrogen levels encourage your body to make more fat cells which leads to vicious cycle. When the body can’t metabolize estrogen, it gets stored in fat cells where it can recirculate and cause estrogen dominant symptoms (Such as estrogen related cancers, endometriosis, fibrocystic breasts, fibroids, PMS)   Genetic variants involved in Phase 1 and 2 of estrogen metabolism As I mentioned, estrogen is broken down in the liver and the gut by various enzymes. Methylation: COMT and MTHFR COMT stands for catechol-O-methyltransferase. It breaks down certain neurotransmitters and estrogen. When the activity of COMT is slow, it means you are likely to have higher levels of estrogen in your body, which is great if it stays balanced. Estrogen gives you glowing skin, it increases dopamine and thus helps you to feel motivation and pleasure and it acts as natural anti-depressant.  The problem lies in our diet and lifestyle and our exposure to those xenoestrogens. The more you take those in, the more they build up and the slower this enzyme works. The result? Estrogen dominance. Estrogen dominance can make you feel irritable, annoyed, aggressive and argumentative and anxious.   MTHFR MTHFR decresed activity has been associated with long duration of estrogen exposure. Someone with this enzyme can end up with two different kinds of estrogen and their metabolites circulating in their bloodstream. This is seen in an increased risk for premenopausal breast cancer. CYP450 enzymes These gene variants are involved in phase 1 liver detoxification that identify and convert fat soluble compounds coming in through our diet, lifestyle and environment into water soluble so that they can be excreted safely. However when there is altered activity in these enzymes, it can lead to the estrogen getting metabolized down a harmful pathway, which can cause health issues. (everything you eat, breath in and put on your body needs to go through this process) Oxidative Stress enzymes This is known as your intermediate phase, Once the enzymes in phase 1 have identified and converted the compounds, they wait to be processed by phase 2 enzymes, but during this waiting period they are potentially harmful and cause oxidative stress. Oxidative stress means free radicals are generated . Free radicals are a potentially harmful by product that can damage cells and cause illness and accelerate aging. We need the help of antioxidants from nutrients to neutralize them. GST enzymes These enzymes are involved in phase 2 detoxification where they neutralize the potentially harmful compounds and get them ready for excretion. There are a few different processes that make this happen and one of them is using glutathione which is a powerful antioxidant to neutralize free radicals.   Phase 3: elimination Phase 3 is the last phase that relies on the gallbladder, intestines. Your liver packages waste products into bile, stores them in the gallbladder, and releases them into the intestines upon fat consumption, eventually exiting the body through stool. Waste is also removed by sweat and urine. Your body does not rely on enzymes alone to do this.  It needs the right nutrients coming in through your diet (antioxidants). If you you are exposed to many xenoestrogens through diet, lifestyle and environment, if you have genetic mutations and if you have a poor diet, this will all affect your body’s ability to detox estrogen properly, which means estrogen dominance.   Thrive By Design Membership Thrive by Design helps you learn to support your genes through epigenetics . Your genes are the blueprint, but you are the architect.   Take Action As you can see this is an important

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What you need to know about Perimenopause

What is Perimenopause? Perimenopause is the time in a woman’s life where her hormones begin to shift. Her body is preparing her for menopause (the cessation of her child-bearing years and menstruation). This can begin in your late thirties, but normally by the time you hit your forties, you would of started perimenapause. This stage can last 7-10 years before menopause. What Changes can I expect? In perimenopause, you produce less estrogen, progesterone and testosterone. As progesterone slows down, ovulation stops occurring regularly. Your hormones begin to change and this can result in weight gain, insomnia, and thin/dry/itchy skin to name but a few changes. If you want to get through the next decade without feeling terrible, there are plenty of proactive things you can do to support your hormones. What changes do I need to make? 1. Balance your blood sugar (regular meals and a balanced plate of protein, complex carbs, healthy fats and fiber) 2. Manage Stress levels (find coping techniques, do enjoyable things, spend time with loved ones) 3. Support your Liver (limit alcohol and sugar intake) 4. Regular exercise (focus on strength training for bone health) 5. Look after your gut health (eat enough, supplement if you need to, hydrate, and eat fiber for detox) 6. Get quality sleep (7-9 hours uninterrupted sleep) what you eat and do 3 hours before bedtime matters/ have a routine 7. Get sunshine everyday! (15 minutes is enough to get Vitamin D) 8. Consider an adaptogen (Adaptogens can help for hormone balance, anxiety and energy) 9. Self-care (taking time for a hobbie and relaxing is important) 10. Mental health (Keep learning and trying new things to exercise your brain) 11. Change your diet (consider upping your antioxidant and protein intake, remember your diet needs to change with you) 12. Keep an eye on your levels (get your nutritional blood levels checked occasionally especially Vitamin D, calcium, B12, Folate and Iron) How your genes are involved Each woman will experience perimenopause differently based on her lifestyle, diet, environment and how these factors influence her unique genetics. If you have problematic genetics in your detoxification pathway, how your body metabolizes and detoxifies estrogen can have a profound effect on how you experience perimenopause as well as your risk factors for ovarian, breast and uterine cancers.   Thrive By Design Membership Thrive by Design helps you learn to support your genes through epigenetics . Your genes are the blueprint, but you are the architect.     The DNA Core and Hormone tests are two highly recommended genetic tests that can give you valuable insight as you age. Send me an email if you want to get this test @bountifullyhealthy

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